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SCIENCE ADVANCES   |  RESEARCH ARTICLE

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        catalog number 104706), and anti-CD86–allophycocyanin (BioLegend,   for improving sonodynamic therapy. Mater. Horizons 7, 2028–2046 (2020).
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        entific, Attune NxT).                                    H. Xu, Y. Chen, Checkpoint blockade and nanosonosensitizer-augmented noninvasive
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        sponses against tumor metastasis, suspensions in tumors were stained    16.  Q. Zhang, C. Bao, X. Cai, L. Jin, L. Sun, Y. Lang, L. Li, Sonodynamic therapy-assisted
        with anti-CD3–PE (BioLegend, catalog number 100308), anti-   immunotherapy: A novel modality for cancer treatment. Cancer Sci. 109, 1330–1345
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                                                                 W. Tao, Ultrasound mediated therapy: Recent progress and challenges in nanoscience.
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                                                                 of mitophagy by “All-in-One” nanosensitizer augments sonodynamic glioma therapy.
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        in our experiments were in a 1:100 dilution from the stock solutions.  chlorin-e6 and its sonodynamic anti-cancer activity in hepatoma-22 tumor-bearing mice.
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        way analysis of variance (ANOVA), two-way ANOVA, or Student’s    22.  B. Chen, R. Zheng, D. Liu, B. Li, J. Lin, W. Zhang, The tumor affinity of chlorin e6 and its
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        included in the corresponding figure legends. Asterisks represent    23.  P. Zhu, Y. Chen, J. Shi, Nanoenzyme-augmented cancer sonodynamic therapy by
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        Supplementary material for this article is available at https://science.org/doi/10.1126/   26.  L. Cao, X. Guo, L. Wang, S. Wang, Y. Li, W. Zhao, Synthesis and in vitro phototoxicity
        sciadv.abj4796                                           of novel -extension derivatives of chlorin e6. New J. Chem. 41, 14279–14287 (2017).
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